Therapeutic Strategies in Acute Intracerebral Hemorrhage
نویسندگان
چکیده
منابع مشابه
White Matter Injury after Intracerebral Hemorrhage: Pathophysiology and Therapeutic Strategies
Intracerebral hemorrhage (ICH) accounts for 10%-30% of all types of stroke. Bleeding within the brain parenchyma causes gray matter (GM) destruction as well as proximal or distal white matter (WM) injury (WMI) due to complex pathophysiological mechanisms. Because WM has a distinct cellular architecture, blood supply pattern and corresponding function, and its response to stroke may vary from th...
متن کاملReversal Strategies for Vitamin K Antagonists in Acute Intracerebral Hemorrhage
OBJECTIVE There is little evidence to guide treatment strategies for intracerebral hemorrhage on vitamin K antagonists (VKA-ICH). Treatments utilized in clinical practice include fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC). Our aim was to compare case fatality with different reversal strategies. METHODS We pooled individual ICH patient data from 16 stroke registries in...
متن کاملDynamic cerebral autoregulation in acute intracerebral hemorrhage.
BACKGROUND AND PURPOSE Cerebral autoregulation (CA) is not universally impaired in acute intracerebral hemorrhage (ICH); however, the dynamic components of CA are probably more vulnerable. This study, therefore, evaluates the time course of dynamic CA in acute ICH and its relationship to clinical outcome. METHODS Twenty-six patients with ICH were studied on days 1, 3, and 5 after ictus. Dynam...
متن کاملAcute Management of Anticoagulation-Associated Intracerebral Hemorrhage
One of the most serious forms of stroke is intracerebral hemorrhage (ICH) as fewer than 30 % of patients recover to functional independence and the one-year mortality rate of over 50 % is very high [1–3]. In hemorrhagic stroke, oral anticoagulation-associated intracerebral hemorrhage (OAC-ICH) is of particular concern because it is associated with larger hemorrhage volumes, increased ventricula...
متن کاملTherapeutic Benefit of Intravenous Administration of Human Umbilical Cord Blood- Mononuclear Cells Following Intracerebral Hemorrhage in Rat
Objective(s) Human umbilical cord blood (HUCB) is now considered as a valuable source for stem cell–based therapies. Previous studies showed that intravascular injection of the HUCB significantly improves neurological functional recovery in a rat model of intracerebral hemorrhage (ICH). In the present study, we hypothesize transplanted HUCB derived mononuclear cells (UC-MCs) can decrease injur...
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ژورنال
عنوان ژورنال: Neurotherapeutics
سال: 2011
ISSN: 1933-7213,1878-7479
DOI: 10.1007/s13311-011-0091-8